Release v1.0.0-rc.8 Pre-release#

CORNETO 1.0.0 RC8 improves binary total-variation modeling and fixes iMAT threshold and structured-regularization behavior.

Highlights#

  • Added exact total variation for binary selections, including support for maximizing switch counts and handling zero-weight pairs.

  • Fixed iMAT threshold rewards so flux below the activity threshold remains feasible without receiving the high-expression reward.

  • Avoided unnecessary flux indicators when structured regularization is off, and corrected reaction-union regularization for single-condition models.

Compatibility#

The total-variation API adds an optional exact argument. Its default keeps the existing continuous absolute-value formulation. iMAT now treats its activity threshold as a reward condition rather than a feasibility restriction.

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